Programs which attempt to clean up your machine by automatically removing data they identify as unnecessary may accidentally corrupt your LispWorks executable, because they do not understand its format. This will prevent LispWorks from starting.
Examples are the
cron job on Linux and CleanMyMac on Macintosh. These particular programs should no longer affect LispWorks, but there may be similar utilities in use.
If corruption occurs check if it has been caused by a clean-up utility. If this is the case, firstly configure your clean-up utility to ignore LispWorks, and then reinstall LispWorks.
LispWorks Release Notes and Installation Guide - 23 Dec 2011