LispWorks for Macintosh is supplied with two images. One supports the Cocoa GUI, the other supports the GTK+ GUI (and can load the Motif GUI). You cannot build a Cocoa application using the GTK LispWorks image, and vice versa.
You should use the appropriate image to deliver your application.
For GTK and Motif applications delivered with LispWorks for Macintosh, the issues described in Delivery on Linux, FreeBSD, x86/x64 Solaris and Unix will be relevant.
LispWorks Delivery User Guide - 13 Dec 2011